Cohort Profile: Antiretroviral Therapy in Lower Income Countries (ART-LINC): international collaboration of treatment cohorts
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چکیده
Highly active antiretroviral therapy (HAART), a combination of at least three drugs, has substantially improved the prognosis of HIV-infected patients in industrialized countries. 1–3 In resourcepoor settings in Africa, Asia, and South America, where 90% of people with HIV/AIDS live, access to HAART continues to be limited. It is estimated that one million HIV-1 infected individuals presently receive HAART in low-income and middle-income countries, which represents only 15% of the 6.5 million people urgently in need of such treatment in these settings. 4 International and bilateral initiatives, including WHO’s ‘3 by 5’ target (3 million patients treated by 2005), the Global Fund to fight AIDS, Tuberculosis and Malaria, and the United States President’s Emergency Plan for AIDS Relief (PEPFAR), aim to substantially increase access to antiretroviral treatment in these settings during the next few months. Clinical and epidemiological research has been conducted at the level of selected centres regarding treatment response, 5–8
منابع مشابه
Cohort Profile: Antiretroviral Therapy in Lower Income Countries (ART-LINC): international collaboration of treatment cohorts.
Highly active antiretroviral therapy (HAART), a combination of at least three drugs, has substantially improved the prognosis of HIV-infected patients in industrialized countries. 1–3 In resourcepoor settings in Africa, Asia, and South America, where 90% of people with HIV/AIDS live, access to HAART continues to be limited. It is estimated that one million HIV-1 infected individuals presently r...
متن کاملMortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries The Antiretroviral Therapy in Lower Income Countries (ART-LINC) Collaboration and ART Cohort Collaboration (ART-CC) groups
Introduction The increasingly widespread use of highly active antiretroviral therapy (HAART) since 1996 has substantially improved the prognosis of HIV-infected patients who have access to these drugs. In resourcepoor settings in Africa, Asia, and South America, where 90% of people with HIV/AIDS live, access to HAART is limited. With falling prices of proprietary drugs, the increasing availabil...
متن کاملCohort profile: the paediatric antiretroviral treatment programmes in lower-income countries (KIDS-ART-LINC) collaboration.
The Paediatric Antiretroviral Treatment Programmes in Lower-Income Countries (KIDS-ART-LINC) collaboration (see Appendix for details) is an international epidemiological network in sub-Saharan Africa. The paediatric HIV burden is currently estimated at 2.3 million (1.7–3.5 million) children under 15 years of age worldwide, 90% of them living in subSaharan Africa. Anti-retroviral therapy (ART) i...
متن کاملCohort profile: Antiretroviral Therapy Cohort Collaboration (ART-CC).
The advent of effective combination antiretroviral therapy (ART) in 1996 resulted in fewer patients experiencing clinical events, so that some prognostic analyses of individual cohort studies of human immunodeficiency virus-infected individuals had low statistical power. Because of this, the Antiretroviral Therapy Cohort Collaboration (ART-CC) of HIV cohort studies in Europe and North America w...
متن کاملOutcomes of antiretroviral therapy in children in Asia and Africa: a comparative analysis of the IeDEA pediatric multiregional collaboration.
BACKGROUND We investigated 18-month incidence and determinants of death and loss to follow-up of children after antiretroviral therapy (ART) initiation in a multiregional collaboration in lower-income countries. METHODS HIV-infected children (positive polymerase chain reaction <18 months or positive serology ≥18 months) from International Epidemiologic Databases to Evaluate AIDS cohorts, <16 ...
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